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Cancer: Hepatocellular Carcinoma

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Total 40824 results found since Jan 2013.

Critical Illness–Related Corticosteroid Insufficiency in Cirrhotic Patients With Acute Gastroesophageal Variceal Bleeding: Risk Factors and Association With Outcome*
Objectives: Critical illness–related corticosteroid insufficiency can adversely influence the prognosis of critically ill patients. However, its impact on the outcomes of patients with cirrhosis and acute gastroesophageal variceal bleeding remains unknown. We evaluated adrenal function using short corticotropin stimulation test in patients with cirrhosis and gastroesophageal variceal bleeding. The main outcomes analyzed were 5-day treatment failure and 6-week mortality. Design: Prospective observational study. Setting: Ten-bed gastroenterology-specific medical ICU at a 3,613-bed university teaching hospital in Taiwan. Pa...
Source: Critical Care Medicine - November 18, 2014 Category: Emergency Medicine Tags: Clinical Investigations Source Type: research

Early Radiation Toxicity from Yttrium-90 Radioembolization for Advanced Hepatocellular Carcinoma.
PMID: 26757208 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - January 12, 2016 Category: Respiratory Medicine Authors: Hiensch R, Meinhof K, Nandedkar D, Chun G, Dua S Tags: Am J Respir Crit Care Med Source Type: research

Hepatoma Derived Growth Factor Predicts Disease Severity and Survival in Pulmonary Artery Hypertension.
CONCLUSION: Elevated HDGF was associated with worse functional class, exertional intolerance, and increased mortality in PAH, suggesting HDGF as a potential biomarker for predicting mortality, with possible diagnostic value for distinguishing PAH from non-PAH. HDGF may add additional value in PAH risk stratification in clinical trials as well as represent a potential target for future PAH drug development. PMID: 27254543 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - June 1, 2016 Category: Respiratory Medicine Authors: Yang J, Nies MK, Fu Z, Damico R, Korley FK, Hassoun PM, Ivy DD, Austin ED, Everett AD Tags: Am J Respir Crit Care Med Source Type: research

The Prescient Prognosticator? Hepatoma-derived Growth Factor in Pulmonary Hypertension.
PMID: 27845583 [PubMed - in process]
Source: American Journal of Respiratory and Critical Care Medicine - November 14, 2016 Category: Respiratory Medicine Authors: Kameny RJ, Fineman JR Tags: Am J Respir Crit Care Med Source Type: research

Obstructive Sleep Apnea, Hypoxia, and Nonalcoholic Fatty Liver Disease.
Abstract Recent studies have demonstrated that obstructive sleep apnea (OSA) is associated with the development and evolution of nonalcoholic fatty liver disease (NAFLD), independent of obesity or other shared risk factors. Like OSA, NAFLD is a prevalent disorder associated with major adverse health outcomes: Patients with NAFLD may develop cirrhosis, liver failure, and hepatocellular carcinoma. One major finding that has emerged from these studies is that the OSA/NAFLD association is related to the degree of nocturnal hypoxemia in OSA. Animal models have therefore largely focused on intermittent hypoxia, a key ma...
Source: American Journal of Respiratory and Critical Care Medicine - November 13, 2018 Category: Respiratory Medicine Authors: Mesarwi OA, Loomba R, Malhotra A Tags: Am J Respir Crit Care Med Source Type: research

Sovaldi - a "Revolution" in Clinical Care, or in Marketing and Public Relations?
DiscussionWashington Post/ Kaiser Health NewsOn May 12, 2014, in an article on the dilemma the drug's US price of $1000/ pill presents to Medicare, Richard Knox wrote this about a patient with the infection:Previous drug treatments didn't clear the virus from Bianco's system. But it's almost certain that potent new drugs for hep-C could cure him. In other words, the article asserted that Sovaldi and similar drugs cure nearly everyone with hepatitis C, even those not cured by previous treatment.  ReutersOn May 20, 2014, in an article about how US health insurers are balking at the price of Sovaldi, was this statement b...
Source: Health Care Renewal - May 28, 2014 Category: Health Management Tags: evidence-based medicine Gilead health care prices manipulating clinical research Sovaldi You heard it here first Source Type: blogs

Trends and Social Barriers for Inpatient Palliative Care in Patients With Metastatic Bladder Cancer Receiving Critical Care Therapies.
CONCLUSIONS: The rate of IPC use in patients with mUCB receiving CCTs sharply increased between 2004 and 2015. The presence of liver metastases, infections, or cardiopulmonary disorders as admission diagnoses represented independent predictors of higher IPC use. Conversely, Hispanic race, nonteaching hospital status, and hospitalization in the Midwest were identified as independent predictors of lower IPC use and represent targets for efforts to improve IPC delivery in patients with mUCB receiving CCT. PMID: 31693981 [PubMed - in process]
Source: Journal of the National Comprehensive Cancer Network : JNCCN - November 8, 2019 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

The critical value of remnant liver volume-to-body weight ratio to estimate posthepatectomy liver failure in cirrhotic patients
Abstract: Background: The extensive use of major hepatectomy for liver malignancies with cirrhosis increases the risk of posthepatectomy liver failure (PHLF), which is associated with a high frequency of postoperative complications, mortality, and an increased length of hospital stay. Remnant liver volume-to-body weight ratio (RLV-BWR) is more specific than the ratio of RLV-to-total liver volume (RLV-TLV) in predicting postoperative course after major hepatectomy in normal liver. Patients having normal liver with an anticipated RLV-BWR ≤0.5% are at considerable risk for hepatic dysfunction and postoperative mortality. In...
Source: Journal of Surgical Research - January 27, 2014 Category: Surgery Authors: Xian-Jian Lin, Jie Yang, Xiao-Bo Chen, Ming Zhang, Ming-Qing Xu Tags: Shock/Sepsis/Trauma/Critical Care Source Type: research

Fever of unknown origin (FUO) due to miliary BCG: The diagnostic importance of morning temperature spikes and highly elevated ferritin levels
We present an interesting case of FUO due to miliary BCG without any localizing signs, i.e., no lung, liver or prostate involvement. The only clues to the diagnosis of this FUO due to disseminated BCG were morning temperature spikes and otherwise unexplained highly elevated ferritin levels.
Source: Heart and Lung: The Journal of Acute and Critical Care - February 28, 2017 Category: Respiratory Medicine Source Type: research

Jorge A. Marrero, MD, MS - Surveying the View From the Driver ’s Seat in Hepatocellular Carcinoma: Bringing Into Focus Hepatology’s Key Role in Guiding HCC Care Down the Path to Improved Outcomes
Surveying the View From the Driver’s Seat in Hepatocellular Carcinoma: Bringing Into Focus Hepatology’s Key Role in Guiding HCC Care Down the Path to Improved Outcomes
Source: Peerview CME/CE Video Podcast - Internal Medicine International - January 11, 2019 Category: Internal Medicine Authors: PVI, PeerView Institute for Medical Education Tags: Science, Medicine Source Type: video

Intractable Neck Pain in an Oncologic Palliative Care Setting: Is Cancer Always the Answer?
Authors: Delfine V, Bernasconi E, Bardelli D, Spataro V, Fusi-Schmidhauser T Abstract Refractory pain is a common manifestation in an oncologic palliative care setting and represents a major challenge for health care professionals involved in care provision. The underlying neoplasm and its dissemination are the foremost pathophysiologic mechanism for the development of pain in patients with advanced cancer. Nonetheless, other etiologies such as trauma and infections need to be considered by clinicians in this particular care setting. The authors present the case of a patient with a recent diagnosis of hepatocellula...
Source: Journal of Pain and Palliative Care Pharmacotherapy - March 15, 2017 Category: Palliative Care Tags: J Pain Palliat Care Pharmacother Source Type: research

Hepatocellular carcinoma: considerations for managed care professionals.
Abstract Liver cancer is the most rapidly increasing cancer in the United States and is associated with a high cancer-related mortality. Seventy-five percent of liver cancers are hepatocellular carcinoma (HCC) resulting from cirrhosis. Patients are typically diagnosed late in the disease, with a relatively small percentage eligible for curative treatments. Despite the addition of several new therapies for advanced HCC, the 5-year survival rate is just 18%. The direct and indirect costs of HCC are substantial, and are expected to increase with the rise in disease incidence as well as a growing number of high-cost t...
Source: The American Journal of Managed Care - October 1, 2020 Category: Health Management Authors: Bobolts LR Tags: Am J Manag Care Source Type: research

Is There a Role for Statins in Palliative Care for Patients Suffering from Hepatocellular Carcinoma?
Authors: Björkhem-Bergman L PMID: 26514023 [PubMed - in process]
Source: Journal of Palliative Care - November 1, 2015 Category: Palliative Care Tags: J Palliat Care Source Type: research

Tropical Travel Trouble 005 RUQ Pain and Jaundice
LITFL • Life in the Fast Lane Medical Blog LITFL • Life in the Fast Lane Medical Blog - Emergency medicine and critical care medical education blog aka Tropical Travel Trouble 005 Guest Post: Dr Branden Skarpiak – Global Health Fellow, Department of Emergency Medicine. UT Health San Antonio A 35 year old male presents to your emergency room for right upper quadrant pain that has gotten worse over the last 2-3 days. He also describes associated nausea, vomiting, and fevers. He denies other abdominal pain, or change in his bowel or bladder habits. His wife notes that he has started to “look more yellow” recent...
Source: Life in the Fast Lane - March 19, 2018 Category: Emergency Medicine Authors: Neil Long Tags: Clinical Cases Tropical Medicine amebic amoeba amoebiasis amoebic dysentery amoebic liver abscess bloody diarrhoea e.dispar e.histolytica entamoeba histolytica Source Type: blogs

NF κB and Kidney Injury
Conclusion As a critical regulator of inflammation and cell survival, the NFκB pathway is a promising target for diagnosing and treating kidney diseases. For modulation of the NFκB pathway in the clinic, a number of molecules can effectively inhibit NFκB signaling by targeting the receptors, associated adaptors, IKKs, IκBs and transcriptional regulators (144). There is further clinical evidence on small-molecule inhibitors of IKKα and NIK from recent trials on anti-cancer therapies (145). These clinical trials showed that the cancer-selective pharmacodynamic response of DTP3, the co...
Source: Frontiers in Immunology - April 15, 2019 Category: Allergy & Immunology Source Type: research